|
|
| |
New Gout Drugs ??? Pegloticase Continues Its Hopeful Path
In May 2008 the U.S. based company developing Pegloticase made another upbeat statement assessment of what they have learnt in its Phase 3 and open label extension trials. Note that Pegloticase still awaits approval from medical authorities so I am writing here about a new gout drug that is still under development.
May was a good month for gout sufferers. Febuxostat, (EU trade/brand name Adenuric), the first new major drug medication for gout in over 40 years, was approved for marketing in member countries of the European Union.
 |
#1 Doctor Recommended Remedy
People Said About Goutezol Gout Treatment
| "My big toe was in horrible pain, so i went to emergency room. Dr diagnosed gout in my foot and gave me pain killers. I did some googling and found goutezol. I like that it's natural with no chemicals in it. Ive been taking it for about 6 months and so far no attack, and my doc confirmed lower uric acid in my blood. thank you!" Jeff, NY |
 |
HOW PEGLOTICASE WORKS
What makes Pegloticase a very interesting, and more importantly, a hopeful new gout drug, is the way it works. All drugs used in gout try to cure or alleviate the disease by reducing the body's uric acid (UA) levels. They do this by either inhibiting its production or making it easier to remove.
In the world of natural gout remedies, uric acid's removal can be improved by making it more soluble. This is achieved by drinking lots of water and by raising body pH levels in various ways.
Pegloticase's answer to the excess uric acid level problem is to remove it by ingeniously converting uric acid into something else, a substance called Allantoin. Allantoin is more soluble and better excreted than uric acid. The principle comes from the way most animals do it. They do it by converting UA to Allantoin, but this is something humans cannot do naturally. Hence the formulation of Pegloticase.
TRIAL SUCCESS WITH DIFFICULT TO TREAT GOUT PATIENTS
Pegloticase is significant because its trials have focused on gout patients who have not had success with other gout drugs, or who have medical conditions which prohibit the use of them. Thus it has been tackling harder-to-treat gout cases, not the easier ones. Hard to treat cases are a significant percentage of the gout sufferer universe.
It has been having a decent degree of success.
Elimination of gout attacks In its most recent statement the developing company's most significant remark was that the extension trial group receiving Pegloticase every two weeks, there were only four gout attacks among those who had been administered Pegloticase (8 mg) every fortnight for two months, in subsequent months. And none in this group had a gout attack after five months of Pegloticase treatment, in following months. All were patients who had been through a phase 3 trial.
|
|
Save 40% Off The Retail Price
People Said About Goutezol Gout Treatment
| "I've been suffering from gout for over 3 years. I tried many different remedies. After taking your product for 20 days I felt the difference. I'm ordering 3 more bottles to make sure I'm not going to have attack any time soon." Bill, FL |
|
In other patient groups there were reductions in attacks and improvement in tophi reduction. Tophi are those knobbly shaped, awkward looking, lumps of MSU crystals that often develop in longer term gout sufferers.
31% of patients who had not reduced tophi at the end of these phase 3 trials did show tophi reduction in the extension trial. It would seem that the longer a gout sufferer is able to take Pegloticase the more successful it may be, in tophi cases at least.
Other encouraging statements were that all extension trial patients who had responded earlier to treatment and who were on the every two week course maintained normal uric acid levels, (some were new joiners). 70% of those on an every four week course who had responded earlier to treatment, maintained normal uric acid levels.
This suggests that progression of the disease may be contained in difficult-to-treat cases, and therefore may not cause other medical conditions such as kidney stones heart disease and hypertension.
SIDE EFFECTS
Of course Pegloticase has caused side effects, in the extension trial in about 1 in 5 patients. The developing company has said that most were mild, moderate, or controllable. But in some cases more severe side effects have been described as including chest and back pains, muscle cramps, sweating and flushes.
Pegloticase is getting closer to an application for approval by the U.S. FDA. Its developers hope to apply for a Biologics Licence Application in September 2008, and begin marketing it in 2009.
NB. The contents of this article contain medical information not medical advice. Please always discuss gout remedies with your doctor or other health care professional, before implementing any treatment.
|
|
|
|
| |
| |
|
|
|
|
|
|
| |
| |
Learn More about Natural Gout Remedy
According to the National Arthritis Foundation, one in five American adult's suffers from arthritis. This means almost 45 million American's feel this excruciatingly pain consistently. In addition, as the population ages, the number of people experiencing arthritis pain is expected to increase dramatically. So with all of the prescription drugs available to help fight joint pain, why is a tiny... 
It's not unusual for anyone to experience joint pain at any time in their life; overexerting yourself when physically active, not warming up properly before workout routines, and being overweight by even a few pounds can put undue stress on your joints and lead to discomfort or even pain.?? There is some persistent joint paint however that should be given extra consideration, as it may be a...
Gout is a condition that results when crystals of uric acid are deposited body tissues, and is characterized by an overload of this acid. It causes joints to become inflamed and is often very painful. Chronic gout can lead to deposits of hard lumps in and around the joints.
As a result, patients with gout can experience decreased kidney function and kidney stones, which are also very...
Gout is a painful rheumatic disease that affects more than 800 out of every 100,000 individuals. Arthritic gout can occur at any time after puberty until the age of seventy-five. More common in men than women, arthritic gout can cause intense pain in the joints that can last for a few minutes or a few days. Those with gout should see their doctor to see if there are any medications that may...
Joint pain is a common symptom with many possible causes.
There are many possible causes of joint pain. The causes can be divided into categories:
wear-and-tear, such as from overuse, injury, or osteoarthritis. Osteoarthritis is the most common form of arthritis, or joint inflammation, conditions that affect metabolism, such as gout and pseudo gout.
These conditions...
cherry juice good for gout | which foods contain purine | herbal supplement for gout | how to eliminate uric acid | gout and how to prevent it | what foods contain purines |
So you Have Gout!
honey and gout
menus for gout sufferers
pics of gout in big toe
smoked salmon high uric acid
gluten free beer/gout
salmon gout
is salmon bad for gout
does oatmeal cause inflammation
Gout Toe Pics
triphala and gout?
|
|
|
| |
| |
|
|
| |
|
|
|
|
